Does Size Really Matter in Flash Chromatography? Part 2

In a previous post I talked about column size, specifically long-thin versus short-fat and the impact of the cartridge’s dimensions on purification performance. With that comparison I showed that in preparative chromatography, purification efficiency is more about the amount of silica than column dimensions. Cartridges of different dimensions containing the same amount of the same media will provide the same separation efficiency.

But there are other chromatographic aspects where size can impact performance. In this post I will focus on some areas where size does matter – media particle size and media surface area.

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Published by

Bob Bickler

Technical Specialist, Biotage

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