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Isolera™ Dalton

Bringing Mass Detection to Flash Chromatography

Flash Chromatography and Mass Detection System Isolera Dalton
ISO-DALT-DET ISO-DALT-DET Flash Chromatography System Isolera Dalton Screenshot ISO-DALT-NLINK isolera dalton direct interface ISO-DALT-NLINK

Isolera™ Dalton is the most advanced and innovative flash purification system available, designed by people who understand flash chromatography for the chemists who need it.

"Pure convenience! Just pure convenience! It lets us perform purification and analysis at the same time. It gives us tremendous power to isolate unknown compounds.”

- Hiroki Nishii, Chugai Pharmaceutical’s Kamakura Research Laboratories

The Isolera™ Dalton system consists of Isolera™ Dalton Mass Detector, Isolera™ Dalton Nanolink and Isolera™ Spektra and embraces ACI™ for efficient and automated purification. Isolera Dalton directs flash fractionation by molecular mass, and in real time.

Streamlined Workflow

Isolera™ Dalton brings mass detection to flash chromatography. This system identifies compounds by mass in real time during Flash separation, leading to greater confidence in purification and a significant saving in time and money. This combination of identification and purification removes complex off-line analytical steps from the workflow, vastly increasing throughput and putting the entire purification and analysis in the hands of the chemist.

Reactor content can be injected directly to identify target masses, which then are transferred directly to the Flash method for mass targeted purification.

Tailored Technology

Isolera™ Dalton automates and takes the hard work out of the compound identification and purification, perfect for chemists whose priorities lie more towards the chemistry than small details of running the analysis. Minimal user intervention required makes it available to chemists unfamiliar with mass detection or those whose priorities lie in compound synthesis rather than analysis.

Isolera™ Dalton Mass Detector uses a chip-based electrospray system with a miniaturized quadrupole and internal vacuum pumps, allowing the system to easily fit in a fume hood, and is capable of handling both normal and reverse-phase samples with ease. 

Intelligent Integration

Seamless interaction between a flash system and a mass detector requires advanced technology and fine tuning. This is all taken care of by the Isolera™ Dalton Nanolink interface, an intelligent sampling device that at any given moment provides Isolera Dalton Mass Detector with the exact amount of sample required, and dynamically adjusts to the solvent effluent flow rate employed in the Flash system.

Isolera™ Spektra software with its graphic user interface provides a straightforward controlling environment, giving easy access to the process.


  • Compound identification by mass during purification and by direct injection
  • Fully automated integration of Flash purification and mass detection via the Isolera™ Dalton Nanolink
  • Automatically accommodates different flash flow rates
  • Simple wizard-based approach to method development
  • Compact system with miniaturized mass detector, easily fits inside a fume hood with no external pumps


Part No. Description Product type Pack Size Price
ISO-SPK ISO-SPK Isolera Spektra Package Accessories 1 Log in for price


Part No. Description Product type Pack Size Price
413711 413711 Mass Detector spray-chip 200 (1pcs) Spare parts 1 Log in for price
413712 413712 Mass Detector Vac-chip 100 (1pcs) Spare parts 1 Log in for price