|Chemical description||Water wettable polystyrene-divinylbenzene incorporating non-ionisable hydroxyl groups|
|Sorbent type||Reversed phase (non-polar), wettable, with no secondary interactions|
|Average particle size||30 µm, 50 µm|
|Pore Diameter||40 Å|
This procedure is recommended for the extraction of a variety of diuretics from urine using non-polar polymeric SPE. The analyte suite includes thiazides, carbonic anhydrase inhibitors, loop and potassium sparring diuretics, with wide ranging pKa and logP values.
Tags: Acetazolamide, Amiloride, Application Notes, Bendoflumethiazide, Bumetanide, Clinical, Column, Diuretics, Ethacrynic acid, Furosemide, Hydrochlorothiazide, Hydroflumethiazide, LC-MS/MS, Methazolamide, Spironolactone, Urine
This procedure is recommended for the extraction of a variety of pharmaceuticals from water using non-polar polymeric SPE. These pharmaceuticals were identified as potential environmental contaminants by the Environment Agency.
Pharmaceuticals, waste water, antibiotics, EVOLUTE,
Tags: Application Notes, Atenolol, Carbamazepine, Citalopram, Column, Diclofenac, Environmental, Erythromycin, Fluoxetine, Fluvoxamine, HPLC, Ibuprofen, Labetalol, Mefenamic, Metoprolol, Oxprenolol, Paroxetine, Pharmaceuticals, Propranolol, Sotalol, Sulfamethoxazole, Trimethoprim, Water
•Extends the range of acidic, basic and neutral compounds that can be extracted using a single generic method, increasing method development productivity•Has an optimized pore structure which reduces the extraction of endogenous matrix components, and leads to cleaner extracts that give fewer matrix effects in LC-MS/MS analysis•Has optimized physical and chemical characteristics that improve reliability of SPE procedures•Has no secondary interactions, allowing the use of pure organic elution solvent to give high recoveries of very low drug concentrations
Tags: Manuals & User Guides
This poster outlines a new method for the extraction of a mixture of peptides from plasma using resin based SPE. Initial method optimization was performed using EVOLUTE ABN before comparison to the streamlined approach without plate conditioning and equilibration using EVOLUTE EXPRESS ABN. Presented at EBF 2012.
EBF, EBF 2012, Peptide, ABN, SPE, Polymer, Polymeric,
Tags: ACTH (1-24), Alpha-Endorphin, Angiotensin Fragment 1-7, Angiotensin II,, Elafin, Helicobacter pylori (2-20), LC-MS/MS, Myelin Glycoprotein fragment (35-55) rat, Peptides, Pharma, Plasma, Posters, Vasoactive Intestinal Fragment 1-12
Vitamin B7 (Biotin) is a water soluble vitamin necessary for cell growth. The method described in this application note achieves high reproducible extraction recoveries of vitamin B7 from serum whi...
Hello I'm trying to develop a quick method to clean up the protein/lipids from fruit and veg to allow me to minimise matrix suppression for the largest range of pesticides possible (acidic/neutral/basic). I was looking at the EVOLUTE ABN as being a good option but was also wondering if the ISOLUTE® SLE+ may be a better option. Any help you can offer would be greatly appreciated, QuEChERS is too manual and I have some automation for the SPE and potential filtration.
Specific advise on the particular suitability of one technique over the other in this case would require more details of the extraction for the fruit & vegetables. Initially, either suggestion would be a good option, but could be tailored to your particular requirements given more information on initial sample preparation.Browse more questions and answers >
EVOLUTE® EXPRESS Sample Preparation products provide robust, reliable SPE, giving ultra pure extracts and high analyte recoveries. Developed specifically for analyte quantification by LC-MS/MS, EVOLUTE sorbents provide a highly effective solution to the problems of ion suppression and matrix effects.
Eliminate conditioning and equilibration with EVOLUTE EXPRESS load-wash-elute SPE