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Biotage® SNAP XL KP-NH

Flash Chromatography Cartridges

SNAP XL flash purification cartridges

The SNAP KP-NH columns in the following sizes have been phased out on October 1st, 2019: 11g, 28g, 55g, 110g, 375g.

Please check out here the corresponding column in the Biotage® Sfär family: Biotage® Sfär Amino Duo

The following formats remain available: 900g, 1800g.

The large-scale SNAP cartridges are targeted to the development-scale chemists synthesizing and/or purifying from 10g to 100+ grams of product across a wide range of chemistries or conditions, and providing seamless scale-up simply and efficiently without method modification. The SNAP XL cartridges will cater for almost all eventualities in large scale purification of small organic molecules. 

SNAP 900 g and 1800 g cartridges are inert, rugged, high-throughput flash cartridges designed to purify large synthetic sample mixtures from tens to hundreds of grams across a range of different chemistries. 

SNAP XL enables chemists to use columns designed for large scale applications instead of using two or three smaller cartridges, with a significant time and cost benefit vs running the same separation with two or more smaller columns.

SNAP XL are rugged and laser welded for safe operation at pressures up to 100 psi(7 bar), enabling high flow rates and use of higher viscosity solvents, and connectivity is done via standard luer lock connections. Operating at flow rates up to 500 mL/min, these cartridges allow to quickly purify large sample masses, saving hours or even days of purification runtime. 

A refillable external dry load vessel with 500g capacity is also available to be attached in series with the SNAP 900g or SNAP 1800g cartridge.


Biotage® KP-NH chemistry shields synthetic organic amines from acidic silanols providing improved selectivity, peak shape, purity and yield. Unlike traditional silica and 1° amine (propyl amine) bonded silica, Biotage KP-NH doesn’t require the use of chlorinated solvents or amine additives.

Biotage® SNAP KP-NH flash cartridges aseparate 2°, 3°, and heterocyclic amines using non-chlorinated solvents. 

The Luer-lock connections operate safely at 100 psi without compression modules and can be used on any flash system.