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AN929 THC Nails

Extraction of THC and its Metabolites from Human Nails - New Application Note

08 January 2020

The testing of alternative matrices in forensic and/or clinical toxicology is gaining popularity, partly due to less invasive means of collection. Matrices such as hair or nail can provide a more rounded picture of abstinence or abuse and associated timeframes.

This application note describes a procedure for sample pre-treatment and extraction of THC and its metabolites from human nail samples, using the Biotage® Lysera for matrix pulverisation, and pre-concentration of the sample prior to clean up using ISOLUTE® SLE+ supported liquid extraction.


  • Tetrahydrocannabinol (THC)
  • 11-Nor-9-carboxy-Δ⁹- tetrahydrocannabinol (THC-COOH)
  • 11-Hydroxy-Δ⁹- tetrahydrocannabinol (THC-OH)
  • Δ9-tetrahydrocannabinolic acid-A (THCAA)
  • Cannabidiol (CBD)
  • Cannabinol (CBN)

Download application note below.

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ISOLUTE® SLE+ Supported Liquid Extraction