In this post, I will look at the impact modifying mobile phase pH can have on reversed-phase separations.
Continue reading Using pH to optimize reversed-phase flash chromatography separations
Have you ever run flash column chromatography with mass detection (Flash-MS) and observed the total ion current or TIC increase during the purification only to find that there was no discernible compound contributing to the effect?
In this post I discuss how I came across this issue and the solution I found to work.
Continue reading How do I remove an annoying MS TIC background?
This article discusses two recent developments in flash purification that have increased cross-over with traditional HPLC techniques: cartridge media properties and new detectors in flash systems.
Continue reading The Lines Between Purification and Analysis are Blurring…