Does particle shape and/or particle size impact flash column chromatography load limits?

There are many factors which influence successful flash column chromatography. One of those factors is sample load which itself is influenced by things like selectivity, efficiency, dissolution solvent, and load technique. Several of these factors I have addressed in previous posts. Of these, selectivity and efficiency are specific to a media’s physical and chemical characteristics.

In this post I will show if particle size and/or particle shape can influence loading capacity.  Additionally, I will show the positive impact that surface area has on flash column chromatography purification.

Find out more about particle shape/size impacts here.

Published by

Bob Bickler

Technical Specialist, Biotage

Leave a Reply

Your email address will not be published. Required fields are marked *