All there is to know about flash purification – a blog by Biotage
Detecting the undetectable in flash column chromatography using wavelength focusing
Sometimes it feels as if organic chemistry and chromatography are a mixture of art and science. Maybe its because of the necessary creativity needed to address the variety of challenges that we face almost daily. Frankly, its what I find most interesting about this world.
One of the bigger challenges facing chemists is the ability to detect and collect compounds with little or no UV absorption during flash purification. In this post I will talk about a technique that I have found to be quite useful when trying to purify mixtures containing one or more poor absorbers.