All there is to know about flash purification – a blog by Biotage
Can reversed-phase flash chromatography purify better than normal-phase?
The answer to this question is yes, reversed-phase can sometimes provide a better separation and thus better purification than normal-phase. When is reversed-phase likely to be the better choice is a different, and likely better, question.
In this post I will try to demonstrate when reversed-phase is likely the better purification mode.